Revital Mane1, Noa Rapaport1 & Ohad Karnieli1,2*, 1 Docoop Technologies, Or-Yehuda, Israel. 2 Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel *ohad@docoop.com

The source of most active pharmaceutical ingredients and therapeutic drugs is the aqueous environment within living organisms. Their main therapeutic targets within the body are mostly surrounded by water; however, many of these compounds tend to be of a hydrophobic nature.

This is achieved, while at the same time eliminating or dramatically reducing the need for commonly used hazardous solvents. All of the three compounds used in the example show the same or better bioavailability and activity as compared to the commonly used solvents - such as DMSO - on cell culture models. We have also shown enhanced stability of the compounds which were stored at room temperature for long periods of time.

We claim that modifying the physical properties of water with RF radiation (which is well known to produce nanobubbles in the liquid water) and stabilizing these nanobubbles using nanoparticles (with their huge surfaces), leads to an aqueous environment which is more similar to the natural cellular environment. The benefits include enhanced solubility, stability and activity of compounds without the need for artificial vectors or hazardous solvents.